If you get the chance to see the Toadies on their current tour, or any tour for that matter, you should. Completely bad ass.
This song is completely awesome and is one of my personal favorites not only because it's so good, but also it had heavy radio rotation even with it's very strong negative content and imagery. I think this is one of those cases where someone thought it would be "pretty" or "poppy" and played it without really listening to it first.
If you don't know what it's about, listen to the lyrics. Should be pretty self explanatory.
edit: This was at Stubb's in Austin, to answer Dr. Miller's query. These guys are so well liked that after they sold out this show well before the show date (Stubb's can hold about 2,200 people), they added two more shows to make it three nights in a row, and then sold those out too. Like I said, completely bad ass.