I'm a fan of any new method, or method improvement that is simple, efficient, straightforward, and useful. While I haven't ever made a sulfonamide that wasn't a protecting group, they are handy for other things, and pop up in drugs as well. These guys got the reaction to work with one set of conditions on electron rich and poor aromatic thiols, a few aliphatic as well, and it appears to be selective and mild as well.
In fact the only things I can negatively comment on at all are that I would have liked to see more aliphatic examples, and acetonitrile is an expensive solvent. However, I bet that within the next year or so people will be buying cars in stupid numbers again, and acetonitrile will come back down in price.
Edit: I somehow gave the wrong journal title, but the right link. Thanks to Dr. Miller for pointing it out.
8 comments:
my neighbor just bought a Hummer H2....what a douche.
According to my favorite news source, the Onion, the cash for clunkers program turned out to be more like trucks for trucks with slightly better mileage.
Acetonitrile prices are directly related to the global production of acrylonitrile. It turns out that acetonitrile is a by-product of the process to make acrylonitrile. From what I understand, there isn't a dedicated acetonitrile synthesis industrially. Maybe they make Hummers out of acrylonitrile?
There are now potential methods to generate it specifically using modifications of acrylonitrile production to increase the percentage of acetonitrile "byproduct", but until the need for huge amounts of ABS (acrylonitrile butadiene styrene) plastics are returned, prices will remain somewhat high.
JOC not org lett.
How about that Ashfeld paper?
Our little Brandon is all grown up now, how cute!
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