I have a huge sodium hydride reaction going today, almost 100g of 60% NaH, so I've been trapped in front of the hood babysitting all afternoon. It's really boring to stare at that reaction and make sure it doesn't vomit fort it's hateful contents, but is exceedingly preferable to the alternative.
While killing time in between additions I was catching up on some journals and saw this beauty:
I'm impressed by any significant amount of work that can be done in two steps, especially since they seem to add two distinct groups and deprotect in those two short steps. I flipped through the article to find the schemes with the method and its application and came to this:
Scheme 2 shows the appending of the steroid moiety and deprotection in 3 steps. I thought that was odd since they weren't doing as much as they supposedly would in the end, and had already exceeded the alloted steps. I read on and they show the application in scheme 3, and it took 4 steps to get it done. I flipped to the last page only to find out that was it. No more schemes, or discussion. The two step synthesis was completen in a paltry four steps. They were even kind enough to point out in the conclusion that they did indeed perform only two steps (highlighted in yellow), in direct conflict with the scheme. Apparently researchers in California can count vessels as steps. I wonder why they didn't go all the way and call it a domino or multi component reaction?
I also wonder how this made it past review.