tag:blogger.com,1999:blog-2396051467285675491.post8909671624166658471..comments2023-06-26T04:44:41.406-04:00Comments on Mad Scientists: some people just can't countscientist 1http://www.blogger.com/profile/15547801546268584913noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-2396051467285675491.post-34225335520442214262009-03-26T17:54:00.000-04:002009-03-26T17:54:00.000-04:00you could teabag it and call it one pot. I just d...you could teabag it and call it one pot. I just did a peptide synthesis in "one step" involving lots of washes, reagent changes, etc etc.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-2396051467285675491.post-9869818220649773982009-03-26T12:03:00.000-04:002009-03-26T12:03:00.000-04:00This reminds me of a paper a student in my group g...This reminds me of a paper a student in my group got to review from Baran. He is a habitual exaggerator of how short his syntheses are. Luckily, we required him to revise his step count. One "step" had an aqueous workup and "filtration" through a silica pad. By these standards, all of my total syntheses are one step. Keep you fingers crossed that the editors hold him to our request.person 1https://www.blogger.com/profile/10058526387538234632noreply@blogger.comtag:blogger.com,1999:blog-2396051467285675491.post-412561881509647352009-03-25T20:23:00.000-04:002009-03-25T20:23:00.000-04:00I should have put the whole paper in there, they p...I should have put the whole paper in there, they propose it as a Sn2 mechanism in an earlier scheme. So whether it is or not, I would think of those two things as one step.<BR/><BR/>I think I'll start referring to purifications as filtrations through a pad of silica with an increasing strength wash. Target compounds in one, incredible, telescope! JACS here I come!scientist 1https://www.blogger.com/profile/15547801546268584913noreply@blogger.comtag:blogger.com,1999:blog-2396051467285675491.post-5164523543702573942009-03-25T20:15:00.000-04:002009-03-25T20:15:00.000-04:00So do you really think that glycosylation or whate...So do you really think that glycosylation or whatever you call goes via an Sn2 mech?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-2396051467285675491.post-65860354426388215992009-03-25T20:08:00.000-04:002009-03-25T20:08:00.000-04:00Someone just needs to publish guidlines for what y...Someone just needs to publish guidlines for what you can call a step. I got told the other day that even if you do a filtration its still a one pot reaction. Interesting considering you need two flasks to filter something.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-2396051467285675491.post-1706703106652507422009-03-25T18:31:00.000-04:002009-03-25T18:31:00.000-04:00weird. maybe if you say it enough, it feels like t...weird. maybe if you say it enough, it feels like two steps.Anonymousnoreply@blogger.com