tag:blogger.com,1999:blog-2396051467285675491.post5022006753169928782..comments2023-06-26T04:44:41.406-04:00Comments on Mad Scientists: The most useful thing Nicolaou has ever donescientist 1http://www.blogger.com/profile/15547801546268584913noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-2396051467285675491.post-50920161189308328812010-02-27T17:05:06.482-05:002010-02-27T17:05:06.482-05:00I can't wait for part 3 of his autobiography, ...I can't wait for part 3 of his autobiography, I mean "Classics 3"!Unknownhttps://www.blogger.com/profile/04954162269015902714noreply@blogger.comtag:blogger.com,1999:blog-2396051467285675491.post-5157893925420002182010-02-27T17:01:57.190-05:002010-02-27T17:01:57.190-05:00Just because this is the most useful thing he was ...Just because this is the most useful thing he was ever done doesn't mean that it's important. It just means all his other stuff really sucks.person 1https://www.blogger.com/profile/10058526387538234632noreply@blogger.comtag:blogger.com,1999:blog-2396051467285675491.post-8309075420225163012010-02-27T15:54:06.832-05:002010-02-27T15:54:06.832-05:00What do you mean "You could probably make a c...What do you mean "You could probably make a career out of republishing ..."?<br /><br />That's the time honored standard method of getting tenure and then famous.scientist 1https://www.blogger.com/profile/15547801546268584913noreply@blogger.comtag:blogger.com,1999:blog-2396051467285675491.post-10205395898741917642010-02-27T15:00:05.255-05:002010-02-27T15:00:05.255-05:00I think you are giving him to much credit, he comb...I think you are giving him to much credit, he combined two known reactions. I guess we won't know how useful this method is until someone can't get anything to work and tries it out and it works better. <br /><br />You could probably make a career out of republishing modern varients of all sorts of forgotten reactions published back in the days in journals not written in english and not readily accessed. <br /><br />I should have filled out a table with the oxone/2-iodobenzoic acid conditions I was using to try and oxidize that 1,2 diol you left me for Noto M, since all it did was cleave it in good yield to the acid.Jimhttps://www.blogger.com/profile/04700404163873035683noreply@blogger.comtag:blogger.com,1999:blog-2396051467285675491.post-8034499962301485402010-02-26T14:20:12.117-05:002010-02-26T14:20:12.117-05:00I thought that was a rather interesting paper with...I thought that was a rather interesting paper with interesting wording such as "The disadvantages involved with these methods (e.g., safety, drastic or inconvenient conditions)" when talking about old methods.<br /><br />So far as I know this method has no advantages over the Johnson-Lemieux, within the aforementioned framework.<br /><br />I, personally, don't look at having water in a reaction as inconvenient, but I do see the absolute requirement of column chromatography to remove reactant by products as pretty inconvenient.<br /><br />So even his 'most useful' work isn't really that useful.scientist 1https://www.blogger.com/profile/15547801546268584913noreply@blogger.com